Calcium so you’re able to Phosphorus Proportion, PTH, and Bone Fitness

Calcium so you’re able to Phosphorus Proportion, PTH, and Bone Fitness

Kemi VE, Karkkainen MU, Karp HJ, Laitinen KA, Lamberg-Allardt CJ

Prices by the Ray Peat, PhD: “The proportion from calcium so you’re able to phosphate is important; for this reason milk products and you will cheddar are very valuable for losing weight, or preventing weight gain. For folks who aren’t extremely effective, low fat milk and cheddar operate better, due to the fact body fat calorie consumption are not called for.”

“The foods large from inside the phosphate, in accordance with calcium, was grain, beans, chicken, and fish. Of several wishing meals contain added phosphate. Delicacies with a higher, safer proportion from calcium to phosphate is actually makes, instance kale, turnip greens, and you can beet greens, and lots of fruits, dairy, and you may parmesan cheese.”

Br J Nutr

“Free unsaturated essential fatty acids turn on the pressure hormonal, and cortisol prevents oxidization out-of sugar and converts they on fatty acids and you can triglycerides. Keeping cortisol and you can be concerned low is the main question. Keeping a premier ratio from calcium supplements in order to phosphate helps to oppose the pressure kcalorie burning.” “Current guide are demonstrating one to too-much phosphate increases soreness, tissues atrophy, calcification from blood vessels, malignant tumors, alzhiemer’s disease, and, as a whole, the fresh process regarding aging.”

2006 Sep;96(3):545-52. Large phosphorus consumption excessively and negatively affect California and you may bone kcalorie burning from inside the a dosage-oriented trends inside the compliment younger lady. Kemi VE, Karkkainen MU, Lamberg-Allardt CJ. California and you can P are one another essential nutrients for bone and they are proven to affect perhaps one of the most crucial regulators away from bone metabolism, parathyroid hormone (PTH). As well big good P intake, normal off West dieting, could well be deleterious to bone through the improved PTH secretion. Pair regulated dosage-response scientific studies are available on the consequences of large P consumption into the guy. We learnt the new brief-label effects of four P dosages towards Ca and you may bones metabolic process inside fourteen suit girls, 20-twenty-eight yrs old, who have been randomized in order to four controlled investigation weeks; ergo each research topic served as her own handle. P enhance amounts from 0 (placebo), 250, 750 otherwise 1500 mg was basically drawn, divided in to around three doses in study date. The dishes served had been similar throughout the for each analysis big date and you can given 495 mg P and you will 250 milligrams Ca. This new P doses affected the new gel PTH (S-PTH) in the a dosage-established trends (P=0.0005). Discover a reduction in serum ionized California focus just in the highest P dosage escort North Las Vegas (P=0.004). The marker out-of bones creation, bone-certain alkaline phosphatase, reduced (P=0.05) and also the bones resorption marker, N-terminal telopeptide from collagen sorts of I, increased as a result on the P dosage (P=0.05). That it controlled dosage-response research indicated that P has actually a serving-dependent effect on S-PTH and you can increases PTH secretion rather whenever California consumption are lowest. Acutely highest P consumption negatively influences limbs kcalorie burning by the coming down limbs development and increasing bones resorption, as expressed by bones k-calorie burning markers.

20 Oct 1. Increased calcium intake does not completely counteract the effects of increased phosphorus intake on bone: an acute dose-response study in healthy females. A high dietary P intake is suggested to have negative effects on bone through increased parathyroid hormone secretion, as high serum parathyroid hormone (S-PTH) concentration increases bone resorption. In many countries the P intake is 2- to 3-fold above dietary guidelines, whereas Ca intake is too low. This combination may not be optimal for bone health. In a previous controlled study, we found that dietary P dose-dependently increased S-PTH and bone resorption and decreased bone formation. The aim of the present study was to investigate the dose-response effects of Ca intake on Ca and bone metabolism with a dietary P intake higher than recommended. Each of the twelve healthy female subjects aged 21-40 years attended three 24-h study sessions, which were randomized with regard to a Ca dose of 0 (control day), 600 or 1200 mg, and each subject served as her own control. The meals on each study day provided 1850 mg P and 480 mg Ca. S-PTH concentration decreased (P < 0.001) and serum ionized Ca concentration increased (P < 0.001) with increasing Ca doses. The bone formation marker, serum bone-specific alkaline phosphatase, did not differ significantly (P = 0.4). By contrast, the bone resorption marker, urinary N-terminal telopeptide of collagen type I, decreased significantly with both Ca doses (P = 0.008). When P intake was above current recommendations, increased Ca intake was beneficial for bone, as indicated by decreased S-PTH concentration and bone resorption. However, not even a high Ca intake could affect bone formation when P intake was excessive.